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KMID : 0385219970070020071
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Korean Journal of Gerontology
1997 Volume.7 No. 2 p.71 ~ p.75
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Effect of Red Ginseng Extract (RGE) on Learning and Memory Impairment Animal Model SAMP8 - II. Feeding Effect of RGE on Oxygen Radicals and Their Scavenger Enzymes of SAMP8 Brain
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Choi Jin-Ho
Kim Dong-Woo
Kim Hyun-Sook
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Abstract
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This study was designed to investigate the effects of red ginseng extract (RGE) extracted with 80% ethanol on oxybgen radicals and their scavenger enzymes of learning and memory impairments SAMP8 (female). Ginseng (Panax ginseng C.A. Meyer) is one of the most plant drugs which has been used as a medicine in Asia. Senescence-accelerated mouse (SAM) P8 were fed basic diets (control group) and experimental diets (RGE group) with 250 ㎎/㎏ BW of RGE for 8 months. Hydroxyl radical and hydrogen peroxide formations in RGE group were significantly inhibited about 20 and 15%, respectively, but superoxide radical formations in RGE group showed almost no change compared with control group. Lipid peroxide (LPO) contents in brain mitochondria and microsomes were significantly inhibited 20 and 15%, respectively, by long-term administration of RGE. Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity of brain membranes in RGE group were significantly increased about 15%, but Mn-SOD showed almost no change compared with control group. These results suggest that the damages of brain cells in learning and memory impairments of SAMP8 may be effectively inhibited by long-term administration of RGE.
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KEYWORD
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Senescence-accelerated mouse (SAM), Panax ginseng C.A. Meyer, Red ginseng, Reactive oxygen species(ROS), Lipid peroxide (LPO), Superoxide dismutase (SOD), Glutathione peroxidase (GSHPx)
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